Human SNP ID | rs10468017 |
---|---|
Human chromosome | chr15 |
Human SNP position | 58386313 |
Pig chromosome | chr1 |
Pig SNP position | 125715800 |
PubMed ID | 21943158 |
---|---|
Journal | BMC Med Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/21943158 |
Study | Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. |
Disease/Trait | Cardiovascular disease risk factors |
Initial sample | 11,683 European ancestry individuals |
Replication sample | NA |
Region | 15q21.3 |
Chromosome id | chr15 |
Chromosome position | 58386313 |
Reported gene | LIPC |
Mapped gene | LOC102724766 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 102724766 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10468017-T |
SNPs | rs10468017 |
Merged | 0 |
SNP id current | 10468017 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.33 |
P value | 0.000000000003 |
Pvalue mlog | 11.5228787452803 |
P value text | (HDL) |
Or beta | 0.104 |
%95 Ci | [0.075-0.133] mmol/l increase |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | high density lipoprotein cholesterol measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004612 |
Study accession | GCST001247 |
PubMed ID | 19060906 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19060906 |
Study | Common variants at 30 loci contribute to polygenic dyslipidemia. |
Disease/Trait | HDL cholesterol |
Initial sample | 19,840 European ancestry individuals |
Replication sample | Up to 20,623 European ancestry individuals |
Region | 15q21.3 |
Chromosome id | chr15 |
Chromosome position | 58386313 |
Reported gene | LIPC |
Mapped gene | LOC102724766 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 102724766 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10468017-T |
SNPs | rs10468017 |
Merged | 0 |
SNP id current | 10468017 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3 |
P value | 8E-23 |
Pvalue mlog | 22.096910013008 |
P value text | |
Or beta | 0.1 |
%95 Ci | [0.06-0.14] s.d. increase |
Platform | Affymetrix, Illumina [~ 2600000] (imputed) |
CNV | N |
Mapped trait | high density lipoprotein cholesterol measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004612 |
Study accession | GCST000290 |
PubMed ID | 21386085 |
Journal | Diabetes |
Link | www.ncbi.nlm.nih.gov/pubmed/21386085 |
Study | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. |
Disease/Trait | Metabolic syndrome (bivariate traits) |
Initial sample | 22,161 European ancestry individuals |
Replication sample | NA |
Region | 15q21.3 |
Chromosome id | chr15 |
Chromosome position | 58386313 |
Reported gene | LIPC |
Mapped gene | LOC102724766 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 102724766 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10468017-C |
SNPs | rs10468017 |
Merged | 0 |
SNP id current | 10468017 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000006 |
Pvalue mlog | 7.22184874961635 |
P value text | (HDLC-WC) |
Or beta | 0.16 |
%95 Ci | [0.10-0.22] unit increase |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | metabolic syndrome |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000195 |
Study accession | GCST001007 |
PubMed ID | 21665990 |
Journal | Hum Mol Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/21665990 |
Study | Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. |
Disease/Trait | Age-related macular degeneration |
Initial sample | 2,594 European ancestry cases, 4,134 European ancestry controls |
Replication sample | 5,640 European ancestry cases, 52,174 European ancestry controls |
Region | 15q21.3 |
Chromosome id | chr15 |
Chromosome position | 58386313 |
Reported gene | LIPC |
Mapped gene | LOC102724766 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 102724766 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10468017-? |
SNPs | rs10468017 |
Merged | 0 |
SNP id current | 10468017 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.71 |
P value | 0.000000000003 |
Pvalue mlog | 11.5228787452803 |
P value text | |
Or beta | 1.19 |
%95 Ci | [NR] |
Platform | Affymetrix [6036699] (imputed) |
CNV | N |
Mapped trait | age-related macular degeneration |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001365 |
Study accession | GCST001100 |
PubMed ID | 22359512 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22359512 |
Study | Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. |
Disease/Trait | Phospholipid levels (plasma) |
Initial sample | 4,034 European ancestry individuals |
Replication sample | NA |
Region | 15q21.3 |
Chromosome id | chr15 |
Chromosome position | 58386313 |
Reported gene | LIPC |
Mapped gene | LOC102724766 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 102724766 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10468017-? |
SNPs | rs10468017 |
Merged | 0 |
SNP id current | 10468017 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 7E-43 |
Pvalue mlog | 42.1549019599857 |
P value text | (levels) |
Or beta | 0 |
%95 Ci | [0.80-4.70] % increase |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | phospholipid measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004639 |
Study accession | GCST001414 |
PubMed ID | 20385826 |
Journal | Proc Natl Acad Sci U S A |
Link | www.ncbi.nlm.nih.gov/pubmed/20385826 |
Study | Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). |
Disease/Trait | Age-related macular degeneration |
Initial sample | 979 cases, 1,709 controls |
Replication sample | 868 European ancestry cases, 410 European ancestry controls, 4,921 cases, 3,824 controls |
Region | 15q21.3 |
Chromosome id | chr15 |
Chromosome position | 58386313 |
Reported gene | LIPC |
Mapped gene | LOC102724766 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 102724766 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10468017-? |
SNPs | rs10468017 |
Merged | 0 |
SNP id current | 10468017 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.7 |
P value | 0.00000001 |
Pvalue mlog | 8 |
P value text | |
Or beta | 1.22 |
%95 Ci | [1.14-1.30] |
Platform | Affymetrix [632932] |
CNV | N |
Mapped trait | age-related macular degeneration |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001365 |
Study accession | GCST000653 |
PubMed ID | 24816252 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24816252 |
Study | An atlas of genetic influences on human blood metabolites. |
Disease/Trait | Blood metabolite levels |
Initial sample | 7,824 European ancestry individuals |
Replication sample | NA |
Region | 15q21.3 |
Chromosome id | chr15 |
Chromosome position | 58386313 |
Reported gene | LIPC |
Mapped gene | LOC102724766 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 102724766 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs10468017-T |
SNPs | rs10468017 |
Merged | 0 |
SNP id current | 10468017 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.29 |
P value | 0.000000000003 |
Pvalue mlog | 11.5228787452803 |
P value text | (1-palmitoylglycerophosphoethanolamine) |
Or beta | 0.019 |
%95 Ci | [0.013-0.025] unit increase |
Platform | Affymetrix, Illumina [2100000] (imputed) |
CNV | N |
Mapped trait | blood metabolite measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005664 |
Study accession | GCST002443 |