SNP Detail For rs10440635
1.Mapping Information
Human SNP ID rs10440635
Human chromosome chr5
Human SNP position 40490688
Pig chromosome chr16
Pig SNP position 26778337
2.Annotation Information
PubMed ID21743469
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21743469
StudyInteraction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Disease/TraitAnkylosing spondylitis
Initial sample3,023 European ancestry cases, 8,779 European ancestry controls
Replication sample2,111 European ancestry cases, 4,483 European ancestry controls
Region5p13.1
Chromosome idchr5
Chromosome position40490688
Reported genePTGER4
Mapped geneLOC105374736 - LOC105374737
Upstream gene id105374736
Downstream gene id105374737
SNP gene ids
Upstream gene distance144133
Downstream gene distance109192
SNP risk allelers10440635-A
SNPsrs10440635
Merged0
SNP id current10440635
Contextregulatory_region_variant
Intergenic1
Allele frequency0.6
P value0.0000003
Pvalue mlog6.52287874528033
P value text
Or beta
%95 Ci
PlatformIllumina [2223620] (imputed)
CNVN
Mapped traitankylosing spondylitis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003898
Study accessionGCST001149