Human SNP ID | rs1032297 |
---|---|
Human chromosome | chr4 |
Human SNP position | 144513592 |
Pig chromosome | chr8 |
Pig SNP position | 89054087 |
PubMed ID | 26634245 |
---|---|
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1 |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 4q31.21 |
Chromosome id | chr4 |
Chromosome position | 144513592 |
Reported gene | Intergenic |
Mapped gene | LOC105377462 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105377462 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1032297-A |
SNPs | rs1032297 |
Merged | 0 |
SNP id current | 1032297 |
Context | downstream_gene_variant |
Intergenic | 0 |
Allele frequency | 0.411 |
P value | 0.0000000000006 |
Pvalue mlog | 12.2218487496163 |
P value text | |
Or beta | 0.068 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | forced expiratory volume, response to bronchodilator |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366 |
Study accession | GCST003262 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio in COPD |
Initial sample | 5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases |
Replication sample | NA |
Region | 4q31.21 |
Chromosome id | chr4 |
Chromosome position | 144513592 |
Reported gene | Intergenic |
Mapped gene | LOC105377462 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105377462 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1032297-A |
SNPs | rs1032297 |
Merged | 0 |
SNP id current | 1032297 |
Context | downstream_gene_variant |
Intergenic | 0 |
Allele frequency | 0.49 |
P value | 0.000005 |
Pvalue mlog | 5.30102999566398 |
P value text | |
Or beta | 0.011 |
%95 Ci | NR unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, chronic obstructive pulmonary disease, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0000341, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003265 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Pre bronchodilator FEV1/FVC ratio |
Initial sample | 6,659 European ancestry current and former smoker individuals |
Replication sample | NA |
Region | 4q31.21 |
Chromosome id | chr4 |
Chromosome position | 144513592 |
Reported gene | LOC646576, HHIP |
Mapped gene | LOC105377462 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105377462 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1032297-? |
SNPs | rs1032297 |
Merged | 0 |
SNP id current | 1032297 |
Context | downstream_gene_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000000004 |
Pvalue mlog | 8.39794000867203 |
P value text | |
Or beta | 0.01537 |
%95 Ci | unit increase |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | FEV/FEC ratio |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003267 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1/FVC ratio |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 4q31.21 |
Chromosome id | chr4 |
Chromosome position | 144513592 |
Reported gene | Intergenic |
Mapped gene | LOC105377462 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105377462 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1032297-A |
SNPs | rs1032297 |
Merged | 0 |
SNP id current | 1032297 |
Context | downstream_gene_variant |
Intergenic | 0 |
Allele frequency | 0.408 |
P value | 0.0000000000000002 |
Pvalue mlog | 15.698970004336 |
P value text | |
Or beta | 0.016 |
%95 Ci | unit decrease |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | response to bronchodilator, FEV/FEC ratio |
Mapped trait URI | http://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713 |
Study accession | GCST003264 |