SNP Detail For rs10245353
1.Mapping Information
Human SNP ID rs10245353
Human chromosome chr7
Human SNP position 25818994
Pig chromosome JH118567-1
Pig SNP position 186398
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region7p15.2
Chromosome idchr7
Chromosome position25818994
Reported geneNFE2L3
Mapped geneLOC105375197 - LOC100506236
Upstream gene id105375197
Downstream gene id100506236
SNP gene ids
Upstream gene distance41798
Downstream gene distance12297
SNP risk allelers10245353-A
SNPsrs10245353
Merged0
SNP id current10245353
Contextintergenic_variant
Intergenic1
Allele frequency0.1961
P value0.0000000000008
Pvalue mlog12.096910013008
P value text(EA, women)
Or beta0.0414
%95 Ci[0.03-0.053] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region7p15.2
Chromosome idchr7
Chromosome position25818994
Reported geneNFE2L3
Mapped geneLOC105375197 - LOC100506236
Upstream gene id105375197
Downstream gene id100506236
SNP gene ids
Upstream gene distance41798
Downstream gene distance12297
SNP risk allelers10245353-A
SNPsrs10245353
Merged0
SNP id current10245353
Contextintergenic_variant
Intergenic1
Allele frequency0.1998
P value0.0000000000000008
Pvalue mlog15.096910013008
P value text(EA)
Or beta0.0348
%95 Ci[0.026-0.043] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region7p15.2
Chromosome idchr7
Chromosome position25818994
Reported geneNFE2L3
Mapped geneLOC105375197 - LOC100506236
Upstream gene id105375197
Downstream gene id100506236
SNP gene ids
Upstream gene distance41798
Downstream gene distance12297
SNP risk allelers10245353-A
SNPsrs10245353
Merged0
SNP id current10245353
Contextintergenic_variant
Intergenic1
Allele frequency0.1977
P value0.0000000000001
Pvalue mlog13
P value text(women)
Or beta0.0423
%95 Ci[0.031-0.053] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region7p15.2
Chromosome idchr7
Chromosome position25818994
Reported geneNFE2L3
Mapped geneLOC105375197 - LOC100506236
Upstream gene id105375197
Downstream gene id100506236
SNP gene ids
Upstream gene distance41798
Downstream gene distance12297
SNP risk allelers10245353-A
SNPsrs10245353
Merged0
SNP id current10245353
Contextintergenic_variant
Intergenic1
Allele frequency0.2047
P value0.0000000000000002
Pvalue mlog15.698970004336
P value text
Or beta0.0347
%95 Ci[0.026-0.043] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782