SNP Detail For rs1021188
1.Mapping Information
Human SNP ID rs1021188
Human chromosome chr13
Human SNP position 42541997
Pig chromosome chr11
Pig SNP position 25233730
2.Annotation Information
PubMed ID21124946
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21124946
StudyGenome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.
Disease/TraitBone mineral density
Initial sample1,934 European ancestry individuals
Replication sampleUp to 3,835 European ancestry individuals
Region13q14.11
Chromosome idchr13
Chromosome position42541997
Reported geneRANKL
Mapped geneLOC105370177 - TNFSF11
Upstream gene id105370177
Downstream gene id8600
SNP gene ids
Upstream gene distance56041
Downstream gene distance20739
SNP risk allelers1021188-C
SNPsrs1021188
Merged0
SNP id current1021188
Contextintergenic_variant
Intergenic1
Allele frequency0.18
P value0.00000000000002
Pvalue mlog13.698970004336
P value text
Or beta3.89
%95 Ci[1.91-5.87] mg/cm3 decrease
PlatformIllumina [2417199] (imputed)
CNVN
Mapped traitbone density
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003923
Study accessionGCST000877
PubMed ID23437003
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23437003
StudyGenetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.
Disease/TraitBone mineral density
Initial sampleup to 5,878 European ancestry individuals
Replication sampleup to 1,052 European ancestry individuals
Region13q14.11
Chromosome idchr13
Chromosome position42541997
Reported geneTNFSF11
Mapped geneLOC105370177 - TNFSF11
Upstream gene id105370177
Downstream gene id8600
SNP gene ids
Upstream gene distance56041
Downstream gene distance20739
SNP risk allelers1021188-C
SNPsrs1021188
Merged0
SNP id current1021188
Contextintergenic_variant
Intergenic1
Allele frequency0.17
P value0.00000000000004
Pvalue mlog13.397940008672
P value text(Cortical vBMD)
Or beta0.15
%95 Ci[0.11-0.19] unit decrease
PlatformIllumina [2401124] (imputed)
CNVN
Mapped traitbone density
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003923
Study accessionGCST001870