SNP Detail For rs10206899
1.Mapping Information
Human SNP ID rs10206899
Human chromosome chr2
Human SNP position 73673773
Pig chromosome chr3
Pig SNP position 72467415
2.Annotation Information
PubMed ID20383145
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20383145
StudyGenetic loci influencing kidney function and chronic kidney disease.
Disease/TraitCreatinine levels
Initial sample23,812 European ancestry individuals
Replication sample16,626 European ancestry individuals
Region2p13.1
Chromosome idchr2
Chromosome position73673773
Reported geneNAT8, TPRKB, DUSP11, NAT8B, ALMS1
Mapped geneALMS1P
Upstream gene id
Downstream gene id
SNP gene ids200420
Upstream gene distance
Downstream gene distance
SNP risk allelers10206899-G
SNPsrs10206899
Merged0
SNP id current10206899
Contextintron_variant
Intergenic0
Allele frequency0.22
P value0.000000000000001
Pvalue mlog15
P value text
Or beta1
%95 Ci[0.7-1.2] % decrease
PlatformAffymetrix, Illumina, Perlegen [~ 2600000] (imputed)
CNVN
Mapped traitserum creatinine measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004518
Study accessionGCST000651
PubMed ID23535967
JournalJ Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23535967
StudyUsing multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.
Disease/TraitGlomerular filtration rate
Initial sample9,049 European ancestry individuals
Replication sample
Region2p13.1
Chromosome idchr2
Chromosome position73673773
Reported geneNAT8
Mapped geneALMS1P
Upstream gene id
Downstream gene id
SNP gene ids200420
Upstream gene distance
Downstream gene distance
SNP risk allelers10206899-C
SNPsrs10206899
Merged0
SNP id current10206899
Contextintron_variant
Intergenic0
Allele frequency0.23
P value0.00000004
Pvalue mlog7.39794000867203
P value text(Single-measure model)
Or beta1.17
%95 Ci[0.76-1.58] unit increase
PlatformAffymetrix [> 2500000] (imputed)
CNVN
Mapped traitglomerular filtration rate
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005208
Study accessionGCST001923
PubMed ID23535967
JournalJ Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23535967
StudyUsing multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.
Disease/TraitGlomerular filtration rate
Initial sample9,049 European ancestry individuals
Replication sample
Region2p13.1
Chromosome idchr2
Chromosome position73673773
Reported geneNAT8
Mapped geneALMS1P
Upstream gene id
Downstream gene id
SNP gene ids200420
Upstream gene distance
Downstream gene distance
SNP risk allelers10206899-C
SNPsrs10206899
Merged0
SNP id current10206899
Contextintron_variant
Intergenic0
Allele frequency0.23
P value0.000000006
Pvalue mlog8.22184874961635
P value text(3-measure model)
Or beta1.1
%95 Ci[0.73-1.47] unit increase
PlatformAffymetrix [> 2500000] (imputed)
CNVN
Mapped traitglomerular filtration rate
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005208
Study accessionGCST001923
PubMed ID23535967
JournalJ Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23535967
StudyUsing multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.
Disease/TraitGlomerular filtration rate
Initial sample9,049 European ancestry individuals
Replication sample
Region2p13.1
Chromosome idchr2
Chromosome position73673773
Reported geneNAT8
Mapped geneALMS1P
Upstream gene id
Downstream gene id
SNP gene ids200420
Upstream gene distance
Downstream gene distance
SNP risk allelers10206899-C
SNPsrs10206899
Merged0
SNP id current10206899
Contextintron_variant
Intergenic0
Allele frequency0.23
P value0.000000002
Pvalue mlog8.69897000433601
P value text(6-measure model)
Or beta1.1
%95 Ci[0.75-1.45] unit increase
PlatformAffymetrix [> 2500000] (imputed)
CNVN
Mapped traitglomerular filtration rate
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005208
Study accessionGCST001923
PubMed ID24816252
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24816252
StudyAn atlas of genetic influences on human blood metabolites.
Disease/TraitBlood metabolite levels
Initial sample7,824 European ancestry individuals
Replication sampleNA
Region2p13.1
Chromosome idchr2
Chromosome position73673773
Reported geneNAT8
Mapped geneALMS1P
Upstream gene id
Downstream gene id
SNP gene ids200420
Upstream gene distance
Downstream gene distance
SNP risk allelers10206899-T
SNPsrs10206899
Merged0
SNP id current10206899
Contextintron_variant
Intergenic0
Allele frequency0.78
P value5E-481
Pvalue mlog480.301029995663
P value text(N-acetylornithine)
Or beta0.221
%95 Ci[0.21-0.23] unit increase
PlatformAffymetrix, Illumina [2100000] (imputed)
CNVN
Mapped traitblood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002443
PubMed ID24816252
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24816252
StudyAn atlas of genetic influences on human blood metabolites.
Disease/TraitBlood metabolite levels
Initial sample7,824 European ancestry individuals
Replication sampleNA
Region2p13.1
Chromosome idchr2
Chromosome position73673773
Reported geneNAT8
Mapped geneALMS1P
Upstream gene id
Downstream gene id
SNP gene ids200420
Upstream gene distance
Downstream gene distance
SNP risk allelers10206899-T
SNPsrs10206899
Merged0
SNP id current10206899
Contextintron_variant
Intergenic0
Allele frequency0.78
P value8E-123
Pvalue mlog122.096910013008
P value text(X-11787)
Or beta0.04
%95 Ci[0.036-0.044] unit increase
PlatformAffymetrix, Illumina [2100000] (imputed)
CNVN
Mapped traitblood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002443
PubMed ID24816252
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24816252
StudyAn atlas of genetic influences on human blood metabolites.
Disease/TraitBlood metabolite levels
Initial sample7,824 European ancestry individuals
Replication sampleNA
Region2p13.1
Chromosome idchr2
Chromosome position73673773
Reported geneNAT8
Mapped geneALMS1P
Upstream gene id
Downstream gene id
SNP gene ids200420
Upstream gene distance
Downstream gene distance
SNP risk allelers10206899-T
SNPsrs10206899
Merged0
SNP id current10206899
Contextintron_variant
Intergenic0
Allele frequency0.78
P value0.00000000000002
Pvalue mlog13.698970004336
P value text(X-13477)
Or beta0.025
%95 Ci[0.019-0.031] unit increase
PlatformAffymetrix, Illumina [2100000] (imputed)
CNVN
Mapped traitblood metabolite measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005664
Study accessionGCST002443