SNP Detail For rs10189761
1.Mapping Information
Human SNP ID rs10189761
Human chromosome chr2
Human SNP position 646364
Pig chromosome chr3
Pig SNP position 141853449
2.Annotation Information
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitObesity
Initial sample93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
Replication sample65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Region2p25.3
Chromosome idchr2
Chromosome position646364
Reported geneTMEM18
Mapped geneLOC105373353 - TMEM18
Upstream gene id105373353
Downstream gene id129787
SNP gene ids
Upstream gene distance266
Downstream gene distance21609
SNP risk allelers10189761-A
SNPsrs10189761
Merged0
SNP id current10189761
Contextintergenic_variant
Intergenic1
Allele frequency0.82
P value6E-24
Pvalue mlog23.2218487496163
P value text(Obesity class II)
Or beta1.24
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST001953