SNP Detail For rs10152811
1.Mapping Information
Human SNP ID rs10152811
Human chromosome chr15
Human SNP position 86311359
Pig chromosome chr1
Pig SNP position 214898231
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region15q25.3
Chromosome idchr15
Chromosome position86311359
Reported geneAGBL1
Mapped geneAGBL1-AS1, AGBL1
Upstream gene id
Downstream gene id
SNP gene ids727915, 123624
Upstream gene distance
Downstream gene distance
SNP risk allelers10152811-A
SNPsrs10152811
Merged0
SNP id current10152811
Contextintron_variant
Intergenic0
Allele frequency0.69
P value0.0000008
Pvalue mlog6.09691001300805
P value text(AA-triglyceride response)
Or beta18.81
%95 Ci[11.32-26.3] mg/dL decrease
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, triglyceride measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530
Study accessionGCST001859