Human SNP ID | rs1006737 |
---|---|
Human chromosome | chr12 |
Human SNP position | 2236129 |
Pig chromosome | chr5 |
Pig SNP position | 71462856 |
PubMed ID | 18711365 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/18711365 |
Study | Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. |
Disease/Trait | Bipolar disorder |
Initial sample | 4,387 European ancestry cases, 6,209 European ancestry controls |
Replication sample | NA |
Region | 12p13.33 |
Chromosome id | chr12 |
Chromosome position | 2236129 |
Reported gene | CACNA1C |
Mapped gene | CACNA1C |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1006737-A |
SNPs | rs1006737 |
Merged | 0 |
SNP id current | 1006737 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.32 |
P value | 0.00000007 |
Pvalue mlog | 7.15490195998574 |
P value text | |
Or beta | 1.18 |
%95 Ci | [NR] |
Platform | Affymetrix [1769948] (imputed) |
CNV | N |
Mapped trait | bipolar disorder |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000289 |
Study accession | GCST000220 |
PubMed ID | 23974872 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23974872 |
Study | Genome-wide association analysis identifies 13 new risk loci for schizophrenia. |
Disease/Trait | Schizophrenia |
Initial sample | 5,001 European ancestry cases, 6,243 European ancestry controls, 8,832 cases, 12,067 controls |
Replication sample | 4,801 European ancestry cases, 4,741 European ancestry controls, 2,612 European and unknown ancestry cases, 15,021 European and unknown ancestry controls, 581 trios |
Region | 12p13.33 |
Chromosome id | chr12 |
Chromosome position | 2236129 |
Reported gene | CACNA1C |
Mapped gene | CACNA1C |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1006737-A |
SNPs | rs1006737 |
Merged | 0 |
SNP id current | 1006737 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.332 |
P value | 0.000000000005 |
Pvalue mlog | 11.3010299956639 |
P value text | |
Or beta | 1.103 |
%95 Ci | [1.08-1.13] |
Platform | Affymetrix, Illumina [9871789] |
CNV | N |
Mapped trait | schizophrenia |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000692 |
Study accession | GCST002149 |
PubMed ID | 24280982 |
Journal | Mol Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/24280982 |
Study | Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. |
Disease/Trait | Schizophrenia or bipolar disorder |
Initial sample | Up to 4,528 European ancestry schizophrenia cases, up to 4,841 schizophrenia cases, up to 7,362 European ancestry bipolar disorder cases, up to 3,048 bipolar disorder cases, up to 11,637 European ancestry controls, up to 7,786 controls |
Replication sample | NA |
Region | 12p13.33 |
Chromosome id | chr12 |
Chromosome position | 2236129 |
Reported gene | CACNA1C |
Mapped gene | CACNA1C |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1006737-? |
SNPs | rs1006737 |
Merged | 0 |
SNP id current | 1006737 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | |
P value | 0.0000000000006 |
Pvalue mlog | 12.2218487496163 |
P value text | (SCZ or BP vs. controls) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 1100000] (imputed) |
CNV | N |
Mapped trait | schizophrenia, bipolar disorder |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000692, http://www.ebi.ac.uk/efo/EFO_0000289 |
Study accession | GCST002295 |
PubMed ID | 23453885 |
Journal | Lancet |
Link | www.ncbi.nlm.nih.gov/pubmed/23453885 |
Study | Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. |
Disease/Trait | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) |
Initial sample | 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder tr |
Replication sample | NA |
Region | 12p13.33 |
Chromosome id | chr12 |
Chromosome position | 2236129 |
Reported gene | DCP1B, CACNA1C |
Mapped gene | CACNA1C |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1006737-? |
SNPs | rs1006737 |
Merged | 0 |
SNP id current | 1006737 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000000005 |
Pvalue mlog | 8.30102999566398 |
P value text | (5 degree of freedom test) |
Or beta | 1.071 |
%95 Ci | [1.05-1.10] |
Platform | NR [1252901] (imputed) |
CNV | N |
Mapped trait | attention deficit hyperactivity disorder, unipolar depression, schizophrenia, autism spectrum disorder, bipolar disorder |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003888, http://www.ebi.ac.uk/efo/EFO_0003761, http://www.ebi.ac.uk/efo/EFO_0000692, http://www.ebi.ac.uk/efo/EFO_0003756, http://www.ebi.ac.uk/efo/EFO_0000289 |
Study accession | GCST001877 |
PubMed ID | 24280982 |
Journal | Mol Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/24280982 |
Study | Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. |
Disease/Trait | Schizophrenia or bipolar disorder |
Initial sample | Up to 4,528 European ancestry schizophrenia cases, up to 4,841 schizophrenia cases, up to 7,362 European ancestry bipolar disorder cases, up to 3,048 bipolar disorder cases, up to 11,637 European ancestry controls, up to 7,786 controls |
Replication sample | NA |
Region | 12p13.33 |
Chromosome id | chr12 |
Chromosome position | 2236129 |
Reported gene | CACNA1C |
Mapped gene | CACNA1C |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1006737-? |
SNPs | rs1006737 |
Merged | 0 |
SNP id current | 1006737 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000007 |
Pvalue mlog | 7.15490195998574 |
P value text | (BP vs. controls) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 1100000] (imputed) |
CNV | N |
Mapped trait | bipolar disorder |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000289 |
Study accession | GCST002295 |
PubMed ID | 24280982 |
Journal | Mol Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/24280982 |
Study | Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. |
Disease/Trait | Schizophrenia or bipolar disorder |
Initial sample | Up to 4,528 European ancestry schizophrenia cases, up to 4,841 schizophrenia cases, up to 7,362 European ancestry bipolar disorder cases, up to 3,048 bipolar disorder cases, up to 11,637 European ancestry controls, up to 7,786 controls |
Replication sample | NA |
Region | 12p13.33 |
Chromosome id | chr12 |
Chromosome position | 2236129 |
Reported gene | CACNA1C |
Mapped gene | CACNA1C |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1006737-? |
SNPs | rs1006737 |
Merged | 0 |
SNP id current | 1006737 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | (SCZ vs. controls) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 1100000] (imputed) |
CNV | N |
Mapped trait | schizophrenia |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000692 |
Study accession | GCST002295 |
PubMed ID | 20351715 |
Journal | Mol Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/20351715 |
Study | Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. |
Disease/Trait | Bipolar disorder or major depressive disorder (combined) |
Initial sample | 4,387 European ancestry bipolar cases, 1,695 European ancestry major depressive disorder cases, 7,970 European ancestry controls |
Replication sample | NA |
Region | 12p13.33 |
Chromosome id | chr12 |
Chromosome position | 2236129 |
Reported gene | CACNA1C |
Mapped gene | CACNA1C |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 775 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs1006737-? |
SNPs | rs1006737 |
Merged | 0 |
SNP id current | 1006737 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000003 |
Pvalue mlog | 7.52287874528033 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Perlegen [1472580] (imputed) |
CNV | N |
Mapped trait | unipolar depression, bipolar disorder |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003761, http://www.ebi.ac.uk/efo/EFO_0000289 |
Study accession | GCST000641 |