SNP Detail For rs10032216
1.Mapping Information
Human SNP ID rs10032216
Human chromosome chr4
Human SNP position 148748354
Pig chromosome chr8
Pig SNP position 85058161
2.Annotation Information
PubMed ID23408906
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23408906
StudyA meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
Disease/TraitThyroid hormone levels
Initial sampleup to 14,459 European ancestry females, up to 10,936 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males
Replication sampleNA
Region4q31.23
Chromosome idchr4
Chromosome position148748354
Reported geneNR3C2
Mapped geneLOC105377482 - LOC105377481
Upstream gene id105377482
Downstream gene id105377481
SNP gene ids
Upstream gene distance27997
Downstream gene distance35539
SNP risk allelers10032216-T
SNPsrs10032216
Merged0
SNP id current10032216
Contextintergenic_variant
Intergenic1
Allele frequency0.781
P value0.0000000000000009
Pvalue mlog15.0457574905606
P value text(TSH)
Or beta0.087
%95 Ci[0.065-0.109] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitthyroid stimulating hormone measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004748
Study accessionGCST001856
PubMed ID23408906
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23408906
StudyA meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
Disease/TraitThyroid hormone levels
Initial sampleup to 14,459 European ancestry females, up to 10,936 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males
Replication sampleNA
Region4q31.23
Chromosome idchr4
Chromosome position148748354
Reported geneNR3C2
Mapped geneLOC105377482 - LOC105377481
Upstream gene id105377482
Downstream gene id105377481
SNP gene ids
Upstream gene distance27997
Downstream gene distance35539
SNP risk allelers10032216-T
SNPsrs10032216
Merged0
SNP id current10032216
Contextintergenic_variant
Intergenic1
Allele frequency0.781
P value0.0000000000002
Pvalue mlog12.698970004336
P value text(TSH - Females)
Or beta0.106
%95 Ci[0.079-0.133] unit increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitthyroid stimulating hormone measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004748
Study accessionGCST001856